Team Engineering
Using innovative engineering approaches, the Urogenital Engineering group is developing new methods to diagnose and treat diseases of the urinary tract with special focus on the underactive bladder, overactive bladder, incontinence and kidney/ureteral stones.
Dr. Lukas Bereuter
Senior engineer
After an apprenticeship as electronics technician, Lukas Bereuter studied Systems Engineering with a focus on mechatronics at the Zurich University of Applied Sciences (2009-2012). Following this, he did a Master's degree in Biomedical Engineering at the University of Bern (2012-2014). After some months as research assistant, Lucas started his PhD in Biomedical Engineering at the ARTORG Center and Bern University Hospital (2015-2018). In 2019, he joined the Urogenital Engineering group to work on a novel non-invasive medical device to aid bladder emptying in urinary retention patients.
Dr. Shaokai Zheng
DPhil Imperial College London
Shaokai Zheng completed his Bachelor’s degree in Engineering Mechanics at Beijing University of Aeronautics and Astronautics. Then he obtained an MSc in Aerospace Engineering from University of Minnesota, and a DPhil from Imperial College London. Kai is interested in the field of experimental fluid mechanics. He joined the Urogenital Engineering Group at University of Bern as a Postdoctoral Researcher since 2019.
Latest Projects
Our World’s First Non-invasive Solution for Urinary Retention (Innosuisse grant 41236-1 with Bern University Hospital & EPFL)
The UGE group is developing the world’s first non-invasive solution for urinary retention. Patients suffering from urinary retention are unable to empty their bladder because of either a weak bladder muscle or/and a bladder outlet obstruction (e.g. enlarged prostate in men). Read More
Interplay Between Fluid Mechanics and Encrustation/Biofilm Development in Stented Ureters (SNF grant ## IZCOZ0_182966 with Bern University Hospital, University of Oxford and University of Southampton)
Ureters are conducts conveying urine from kidneys into the bladder. Under obstructed conditions of the ureter (e.g. kidney/ureteral stones or tumours), ureteral stents are frequently used in clinical setting to maintain the drainage of urine. Read More
Assessment of Encrustation on Ureteral Stents Retrieved from Patients (with Bern University Hospital)
Ureteral stents, once implanted in patients, are exposed to complex fluid dynamic and chemical (bacteria, crystals) environments. Current projects at UGE involve volumetric and chemical characterisations of encrustation (on ureteral stents retrieved from patients) by means of micro-computed tomography (µCT)... Read More
Innovative Tools for Diagnosis and Treatment of Overactive Bladder and Incontinence (with Bern University Hospital & Bern University of Applied Sciences)
Patients suffering from overactive bladder (OAB) live with a continuous urge to urinate even at low bladder filling volumes, often leading to incontinence. OAB has an enormous impact on the quality of life of affected patients. Read More
Grants
2020
Innosuisse grant without implementation partner Project: ‘41236.1 IP-LS - Feasibility study of a handheld device for non-invasive bladder emptying’2019
Proof-of-Concept grant - University of Bern Project: ‘URODEA: world’s first solution for urinary retention’ elit.2019
2019
Swiss National Science Foundation (SNSF) grant Project: IZCOZ0 182966 - Development and validation of a biologically inspired in vitro platform for long-term assessment of commercial and innovative ureteral stents’2018
COST: European Cooperation in Science and Technology Project: CA16217 - European network of multidisciplinary research to improve the urinary stents (ENIUS)2017
Awards
Project: ‘Urodea: world’s first non-invasive solution for urinary retention’
Start-up weekend Biel (1st place)Project: ‘Urodea: innovative solution for urinary retention’
Publications
2021
Almanza M.*, Clavica F., Chavanne J., Moser D., Obrist D., Carrel T., Civet Y., Perriard Y. ‘Feasibility of a Dielectric Elastomer Augmented Aorta’ Advanced Science2021
Mantegazza A.*, Ungari M., Clavica F., Obrist D. ‘Local versus global blood flow modulation in artificial microvascular networks: effects on red blood cell distribution and partitioning’ Frontiers in Physiology25th September 2020
Mantegazza A.*, Clavica F., Obrist D. ‘In vitro investigations of red blood cell phase separation in a complex microchannel network’ Biomicrofluidics, 20202st January 2020
Chakrabarty B., Bijos D., Vahabi B., Clavica F., Kanai A.J., Pickering A., Fry C., Drake M.J.* ‘Modulation of Micromotions Alters Intravesical Pressure in the Rat Bladder’ Frontiers in Physiology, 9:1937, 201910th January 2019
Haeberlin A., Schurch K.,Niederhauser T.,Sweda R. Schneider M. P. Obrist D., Burkhard F., Clavica F.* ‘Cardiac electrophysiology catheters for electrophysiological assessments of the lower urinary tract - an ex vivo feasibility study in living ureters’ Neurourology and Urodynamics 87-96, 20193rd September 2018
LNiederhauser T., Gafner E, Cantieni T., Grämiger M., Haeberlin A., Obrist D., Burkhard F., Clavica F.* ‘Detection and quantification of overactive bladder activity in patients: Can we make it better and automatic?’ Neurourology and Urodynamics, 1-9, 201826th July 2017
van Asselt E, Choudhary M, Clavica F, van Mastrigt R.* ‘Urethane anesthesia in acute lower urinary tract studies in the male rat.’ Laboratory Animals: 1-7, 201730th June 2016
18th November 2016
Choudhary M.*, Clavica F., van Mastrigt Ron, van Asselt E. ‘A novel single compartment in vitro model for electrophysiological research using the Perfluorocarbon FC-770’, Physiological Research, 20;65(2):341-8, 201624th November 2015
Choudhary M. S., van Asselt E., van Mastrigt R., Clavica F.*, ‘Neurophysiological modelling of bladder afferent activity in the rat overactive bladder model’, Journal of Physiological Sciences, 65(4):329-38, 201518th March 2015
Clavica F.*, Parker K., Khir W. A., ‘Wave intensity analysis in air-filled flexible vessels’, Journal of Biomechanics, 26, 48(4):687-94, 201526th February 2015
Clavica F.*, Choudhary M. S., van Asselt E., van Mastrigt R., ‘Frequency analysis of urinary bladder pre-voiding activity in normal and overactive rat detrusor.’ Neurourology and Urodynamics, vol. 34, pp. 794-9, 20153rd September 2014
Clavica F.*, Zhao X., ElMahdy M., Drake M.J., Zhang X., Carugo D., ‘Beyond the Abstract - A biomimetic artificial model to investigate flow dynamics in the obstructed and stented ureter’, UroToday International Journal 2014May 2014
Clavica F.*, Zhao X., ElMahdy M., Drake M.J., Zhang X., Carugo D., ‘Investigating the flow dynamics in the obstructed and stented ureter by means of a biomimetic artificial model.’ PLOS ONE; 9(2):e87433, 20143rd February 2014
Patents
priority date: 29.01.2019
Clavica F., Obrist D., Burkhard F., Schneider M., 'External impedance pump for emptying the bladder'; Swiss Patent Application CH 00096/19priority date: 29.01.2019